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Specifically: Ipamorelin does not meaningfully stimulate cortisol or aldosterone release (unlike GHRP-2/6), which are the primary peptide-mediated mechanisms for blood pressure elevation Standard ipamorelin doses (200–300 mcg) do not produce clinically significant changes in systolic or diastolic blood pressure in healthy adults based on available clinical data Exception: Immediately post-injection, some users notice transient flushing, a mild warmth, or a brief drop in blood pressure — this resolves quickly and is not a sign of sustained cardiovascular effect If you have hypertension or cardiovascular disease: Discuss with your physician before starting